Revolution Plus and Bravecto are two prescription flea and tick treatments for cats. Both contain drugs from the isoxazoline class, but they differ in what else they cover and how often they’re applied. This comparison is for information only. Your vet should decide which product, if any, is right for your cat.
Bottom Line: Revolution Plus is a monthly topical that covers fleas, some ticks, ear mites, certain intestinal worms and heartworm prevention. Bravecto topical for cats lasts longer between doses for fleas and some ticks, and Bravecto Plus adds heartworm and some worm coverage. Both carry the FDA’s class-wide neurologic warning for isoxazolines.
At a Glance
| Feature | Details |
|---|---|
| Revolution Plus | Selamectin and sarolaner; monthly topical (check current label) |
| Bravecto (cats) | Fluralaner; longer-lasting topical (check current label) |
| Bravecto Plus (cats) | Fluralaner and moxidectin; adds heartworm and some worm coverage |
| Prescription | Both require a vet prescription |
| Drug class | Isoxazoline (sarolaner and fluralaner) |
What It Is and How It Works
Revolution Plus combines selamectin and sarolaner. According to its label, it covers fleas, certain ticks, ear mites, roundworms and hookworms, and prevents heartworm disease. It’s applied monthly.
Bravecto for cats contains fluralaner, applied less often. Bravecto Plus adds moxidectin for heartworm prevention and some intestinal worms.
Age and weight minimums differ, so check each label. See indoor cats flea and tick prevention and comparison of popular pet heartworm medications.
Strengths
- Revolution Plus: broad coverage in one monthly dose, including heartworm prevention
- Bravecto: fewer doses per year for fleas and some ticks
- Both are topical, so no pills
- Both are prescribed after a vet exam
- Both are widely used
Limitations
- Both require a prescription
- Both carry the FDA isoxazoline neurologic warning
- Topicals can cause reactions at the application site
- Cost is higher than many over-the-counter products
Comparison Table
| Feature | Revolution Plus | Bravecto (cats) |
|---|---|---|
| Active ingredients | Selamectin, sarolaner | Fluralaner (plus moxidectin in Bravecto Plus) |
| Dosing | Monthly | Longer interval (check label) |
| Heartworm | Yes | Only Bravecto Plus |
| Ear mites | Yes | Bravecto Plus label includes ear mites (check) |
| Prescription | Yes | Yes |
Labels change, so confirm current coverage with your vet.
Safety Notes and Possible Side Effects
- Isoxazolines carry an FDA neurologic warning.
- Common side effects can include vomiting, itching or hair loss at the application site.
- Follow age and weight minimums.
- Tell your vet about seizure history.
- Never use dog products on cats.
In 2018, the FDA alerted pet owners and vets that isoxazoline products, the drug class that includes sarolaner and fluralaner, have the potential to cause neurologic adverse reactions such as muscle tremors, unsteadiness and seizures. These products remain FDA-approved, and most pets don’t have these reactions, but tell your vet if your cat has a history of seizures or neurologic problems.
Before You Buy
- Ask your vet about your cat’s lifestyle and parasite risks.
- Check the age and weight minimums on each label.
- Decide whether a monthly or longer interval suits you.
- Tell your vet about any seizure or neurologic history.
- Ask whether your cat needs heartworm prevention.
Tips for Using It
- Mark dosing dates on a calendar or set phone reminders.
- Apply to skin at the base of the skull where your cat can’t lick.
- Keep other pets from licking the application site until it dries.
Who It Suits
| Good fit if… | Consider something else if… |
|---|---|
| Your vet recommends prescription parasite control | Your cat has a history of seizures, unless your vet advises otherwise |
| Your cat goes outdoors or lives with dogs that do | Your cat is below the label’s minimum age or weight |
| You want heartworm prevention combined with flea control |
Alternatives to Consider
| Option | How it differs |
|---|---|
| Frontline Plus for cats | Over-the-counter, no heartworm coverage |
| Revolution (selamectin only) | Prescription, no isoxazoline |
| Keeping cats indoors | Lowers, but doesn’t remove, parasite risk |
When to Call Your Vet
Contact your vet if:
- Your cat has tremors, wobbliness or seizures after treatment
- Your cat has a severe skin reaction at the application site
- Your cat vomits repeatedly or seems lethargic
Frequently Asked Questions
Is Revolution Plus or Bravecto better for cats?
It depends on your cat’s risks and your vet’s advice. Revolution Plus covers more parasites in a monthly dose, while Bravecto offers longer gaps between doses for fleas and some ticks.
Do indoor cats need flea and tick prevention?
Indoor cats can still get fleas, often brought in by dogs or people. Heartworm can also affect indoor cats, since mosquitoes come indoors. Ask your vet what your cat needs.
What side effects can these products cause?
Labels list side effects such as vomiting, itching, hair loss or scabbing at the application site. Isoxazolines also carry a warning about neurologic reactions. Contact your vet if you notice any problems.
Can kittens use Revolution Plus or Bravecto?
Each has age and weight minimums on its label. Revolution Plus is labeled for younger kittens than Bravecto. Your vet will choose based on your kitten’s age and size.
Are these products safe for cats with seizures?
The FDA has warned that isoxazolines may cause neurologic reactions, including seizures. Talk to your vet, who may suggest a different product.
Can I bathe my cat after applying a topical?
Follow the label. Many topicals need time to dry and absorb before bathing.
Does Bravecto protect cats against heartworm?
Standard Bravecto for cats doesn’t. Bravecto Plus adds moxidectin, which prevents heartworm disease.
Can I buy Revolution Plus or Bravecto without a prescription?
No. In the United States, both require a prescription from a vet who has examined your cat.
Pet Health Man is independent and isn’t paid by the brands we review. Product formulas, specifications and prices change, so check the current label or the manufacturer’s information before you buy.
This article is for general information only and isn’t a substitute for professional veterinary advice. If you’re worried about your pet’s health, contact your veterinarian or an emergency animal hospital.
